Skip to main content



Genentech WO42633 ASTEFANIA
A Phase III, Randomized, Double-Blind, Placebo-Controlled Clinical Trial to Evaluate the Efficacy and Safety of Adjuvant Atezolizumab or Placebo and Trastuzumab Emtansine for HER2-Positive Breast Cancer at High Risk of Recurrence Following Preoperative Therapy
Minimal Clinically Important Difference in FACIT-Fatigue Scale in patients with locally advanced or metastatic breast cancer receiving treatment with taxane-based chemotherapy
Genentech WO43571heredERA
A Phase III, 2 Arm, Randomized, Open-Label, Multicenter, Registrational Study Evaluating the Efficacy and Safety of Giredestrant in Combination with Phesgo Versus Phesgo (+/- Endocrine Therapy) After Induction Chemotherapy (Phesgo+Taxane) in Patients with Previously Untreated HER2-Positive, Estrogen Receptor Positive Locally Advanced or Metastatic Breast Cancer
AstraZeneca D8534C00001SERENA-6
A Phase III, Double-blind, Randomised Study to Assess Switching to AZD9833 (a Next Generation, Oral SERD) + CDK4/6 Inhibitor (Palbociclib or Abemaciclib) vs Continuing Aromatase Inhibitor (Letrozole or Anastrozole)+ CDK4/6 Inhibitor in HR+/HER2-MBC Patients With Detectable ESR1Mutation Without Disease Progression During 1L Treatment With Aromatase Inhibitor+ CDK4/6 Inhibitor- A ctDNA Guided Early Switch Study
A Phase 2 Study to Evaluate the Safety and Efficacy of Lerociclib in Participants With Advanced Breast Cancer
Celcuity CELC-G-301VIKTORIA-1
A Phase 3, Open-Label, Randomized, Two-Part Study Comparing Gedatolisib in Combination with Palbociclib and Fulvestrant to Standard-of-Care Therapies in Patients with HR-Positive, HER2-Negative Advanced Breast Cancer Previously Treated with a CDK4/6 Inhibitor


Amgen 20190172CodeBreak300
Enrollment on HOLD-A Phase 3 Multicenter, randomized, open-label, active-controlled study of sotorasib and panitumumab versus investigator's choice (Trifluridine and tipiracil, or regorafenib) for the treatment of previously treated metastatic colorectal cancer subjects with KRAS p G12C mutation

Head and Neck



MAJIC: A Phase III Prospective, Multicenter, Randomized, Open-Label Trial of Acalabrutinib plus Venetoclax versus Venetoclax plus Obinutuzumab in Previously Untreated Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
Loxo OncologyLoxo-BTK-20030BRUIN-CLL-314
A Phase 3 Open-Label, Randomized Study of Pirtobrutinib (LOXO-305) versus Ibrutinib in Patients with Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (BRUIN-CLL-314)
Loxo OncologyLOXO-BTK-20020BRUIN CLL-321
A Phase 3, Open-Label, Randomized Study of LOXO-305 versus Investigator's Choice of Idelalisib plus Rituximab or Bendamustine plus Rituximab in BTK Inhibitor Pretreated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (BRUN CLL-321)
Loxo OncologyLOXO-BTK-20022BRUIN CLL-322
A Phase 3 Open-Label, Randomized Study of Fixed Duration Pirtobrutinib (LOXO-305) plus Venetoclax and Rituximab versus Venetoclax and Rituximab in Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (BRUIN CLL-322)

NSC Lung

A Phase III, Randomized, Placebo-controlled, Double-blind, Multi-center, International Study of Durvalumab With Stereotactic Body Radiation Therapy (SBRT) for the Treatment of Patients With Unresected Stage I/II, Lymph-node Negative Non-small Cell Lung Cancer (PACIFIC-4/RTOG-3515) Osimertinib Following SBRT, a Single Arm Cohort for Patients With Unresected Stage I/II, Lymph Node Negative NSCLC Harboring a Sensitizing EGFR Mutation
BMS CA224-104
A Phase 2 Randomized Double-blind Study of Relatlimab plus Nivolumab in Combination with Chemotherapy vs. Nivolumab in Combination with Chemotherapy as First Line Treatment for Participants with Stage IV or Recurrent Non-small Cell Lung Cancer (NSCLC)
Daiichi SankyoDS1062-A-U303TROPION-Lung07
A Randomized Phase 3 Study of Datopotamab Deruxtecan (Dato-DXd) and Pembrolizumab With or Without Platinum Chemotherapy in Subjects With No Prior Therapy for Advanced or Metastatic PD-L1 TPS <50% Non-squamous Non-small Cell Lung Cancer Without Actionable Genomic Alterations (TROPION-Lung07)
Mirati TherapeuticsMRTX- 849-007KRYSTAL-7
A Phase 2 Trial of MRTX849 in Combination with Pembrolizumab in Patients with Advanced Non-Small Cell Lung Cancer with KRAS G12C Mutation
Mirati TherapeuticsMRTX 849-012KRYSTAL-12
A Randomized Phase 3 Study of MRTX849 versus Docetaxel in Patients with Previously Treated Non-Small Cell Lung Cancer with KRAS G12C Mutation
AnHeart TherapeuticsTRUST-II
A Single-Arm, Open-Label, Multicenter Phase 2 Study to Evaluate the Efficacy and Safety of Taletrectinib in Patients With Advanced or Metastatic ROS1 Positive NSCLC and Other Solid Tumors

SC Lung

Daiichi SankyoDS7300-127
A Phase 2, Multicenter, Randomized, Open-label Study of DS-7300a, a B7-H3 Antibody Drug Conjugate (ADC), in Subjects With Pretreated Extensive-stage Small Cell Lung Cancer (ES-SCLC)


An open-label, multicenter, phase II trial evaluating the safety, efficacy, and pharmacokinetics of subcutaneous mosunetuzumab monotherapy in patients with select B-cell malignancies
Genentech MO40598POLARGO
A Phase III, Open-Label, Multicenter, Randomized Study Evaluating the Safety and Efficacy of Polatuzumab Vedotin in Combination with Rituximab Plus Gemcitabine Plus Oxaliplatin (R-GEMOX) Versus R-Gemox Alone in Patients with Relapsed/Refractory Diffuse Large B-Cell Lymphoma
IncyteINCMOR 0208-301InMIND
A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial to Evaluate the Efficacy and Safety of Tafasitamab plus Lenalidomide in Addition to Rituximab Versus Lenalidomide in Addition to Rituximab in Patients with Relapsed/Refractory (R/R) Follicular Lymphoma (FL) Grade 1-3A or R/R Marginal Zone Lymphoma (MZL)
Epizyme EZH-302
A Phase 1B/3 Double-Blind, Randomized, Active-Controlled, 3-Stage, Biomarker Adaptive Study of Tazemetostat or Placebo in Combination with Lenalidomide Plus Rituxumab in Subjects with Relapsed/Refractory Follicular Lymphoma


Multiple Myeloma

Sanofi EFC15992
A Phase 3 Randomized, Open Label, Multicenter Study of Isatuximab (SAR650984) in Combination With Lenalidomide and Dexamethasone Versus Lenalidomide and Dexamethasone in Patients With High-risk Smoldering Multiple Myeloma
Janssen MMY3021AURIGA
A Randomized Study of Daratumumab Plus Lenalidomide Versus Lenalidomide Alone as Maintenance Treatment in Patients with Newly Diagnosed Multiple Myeloma Who Are Minimal Residual Disease Positive After Frontline Autologous Stem Cell Transplant
Oncotherapeutics I-RUX-15-04
A Phase 1 Study of Ruxolitinib, Steroids and Lenalidomide for Relapsed/Refractory Multiple Myeloma (RRMM) Patients

Myelodysplastic Syndromes

Celgene Connect Myeloid
Connect® Myeloid: The Myelofibrosis (MF), Myelodysplastic Syndromes (MDS) and Acute Myeloid Leukemia (AML) Disease Registry
Syros SY-1425-301SELECT MDS-1
A Randomized, Double-blind, Placebo-controlled Phase 3 Study of Tamibarotene Plus Azacitidine Versus Placebo Plus Azacitidine in Newly Diagnosed, Adult Patients Selected for RARA-positive Higher-risk Myelodysplastic Syndrome (SELECT MDS-1)



Novartis CAAA617C12301PSMAddition
PSMAddition: An International Prospective Open-label, Randomized, Phase III Study comparing 177Lu-PSMA-617 in combination with Standard of Care, versus Standard of Care alone, in adult male patients with Metastatic Hormone Sensitive Prostate Cancer (mHSPC)
TEMPUS67652000PCR3002 Amplitude
A Phase 3 Randomized, Placebo-controlled, Double-blind Study of Niraparib in Combination with Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone for the Treatment of Participants with Deleterious Germline or Somatic Homologous Recombination Repair (HRR) Gene-Mutated Metastatic Castration-Sensitive Prostate Cancer (mCSPC)

Solid Tumor

MCLA-128-CL01 Merus
A Phase I/II Study of MCLA-128, a full length IgG1 Bispecific Antibody Targeting HER2 and HER3, in Patients with Solid Tumors
DOT TherapeuticsDay 101-102BFIRELIGHT-01
A Phase 1b/2, Subprotocol of Day101 in Combination with Pimasertib for Patients with Recurrent, Progressive, or Refractory Solid Tumors and MAPK Pathway Aberrations
DOT TherapeuticsDay 101-102AFIRELIGHT-01
A Phase 2, Subprotocol of Day101 Monotherapy for Patients with Recurrent, Progressive, or Refractory Solid Tumors with MAPK Pathway Aberrations
AnHeart Therapeutics TRUST-II
A Single-Arm, Open-Label, Multicenter Phase 2 Study to Evaluate the Efficacy and Safety of Taletrectinib in Patients With Advanced or Metastatic ROS1 Positive NSCLC and Other Solid Tumors

Supportive Care

Lutris Pharma L-02-01
A Phase 2, Randomized, Double-Blind, Placebo-Controlled Efficacy and Safety Study of Topically Administered LUT014 in Metastatic Colorectal Cancer Patients with EGFR Inhibitor Induced Acneiform Lesions


Blood Draw

Tempus Time Trial Program

CSNF is part of The TIME Trial Program, a just-in-time network of providers that supports rapid patient identification, site activation, and enrollment of select clinical trials. Building off of existing relationships with a large network of community hospitals and practices, TIME activates clinical trials at pre-qualified sites in its network in an average of 10 days, bringing the very best clinical trials to community centric parts of this country and giving access to thousands of patients that have historically been denied novel therapeutics. As part of The TIME Trial Network, CSNF has access to the biggest marketplace of trials that can be quickly initiated when there is a patient on-site that is ready to enroll. The program's just-in-time model allows for both sites and sponsors to locate extremely rare patients and then open a trial specifically on that patient’s behalf in a fraction of the time it typically takes.